2018年科研成果

12月

1.     A Shared Neural Node for Multiple Innate Behaviors in Drosophila.

Ho MS. Neurosci Bull. 2018 Dec;34(6):1103-1104. doi: 10.1007/s12264-018-0311-x. Epub 2018 Nov 9

2.       Discovery of a potent HMG-CoA reductase degrader that eliminates statin-induced reductase accumulation and lowers cholesterol.

Jiang SY, Li H, Tang JJ, Wang J, Luo J, Liu B, Wang JK, Shi XJ, Cui HW, Tang J, Yang F, Qi W, Qiu WW, Song BL. Nat Commun. 2018 Dec 3;9(1):5138. doi: 10.1038/s41467-018-07590-3.

3.       Structural and Druggability Landscape of Frizzled G Protein-Coupled Receptors.

Zhang X, Dong S, Xu F. TRENDS IN BIOCHEMICAL SCIENCES, 2018,43(12):1033-1046. doi: 10.1016/j.tibs.2018.09.002. Epub 2018 Oct 8.

4.       α-Synuclein Trafficking in Parkinson's Disease: Insights From Fly and Mouse Models.

Cheng J, Lu Q, Song L, Ho MS. ASN Neuro. 2018 Jan-Dec;10:1759091418812587. doi: 10.1177/1759091418812587.

11月

5.       Engulfing cells promote neuronal regeneration and remove neuronal debris through distinct biochemical functions of CED-1.

Chiu H, Zou Y, Suzuki N, Hsieh YW, Chuang CF, Wu YC, Chang C. Nat Commun. 2018 Nov 19;9(1):4842. doi: 10.1038/s41467-018-07291-x.

6.       CDK7 inhibition is a novel therapeutic strategy against GBM both in vitro and in vivo.

Meng W, Wang J, Wang B, Liu F, Li M, Zhao Y, Zhang C, Li Q, Chen J, Zhang LY, Tang Y, Ma J. Cancer Manag Res. 2018 Nov 15;10:5747-5758. doi: 10.2147/CMAR.S183696. eCollection 2018.

7.       Solid-State NMR Identification of Intermolecular Interactions in Amelogenin Bound to Hydroxyapatite.

Arachchige RJ, Burton SD, Lu JX, Ginovska B, Harding LK, Taylor ME, Tao J, Dohnalkova A, Tarasevich BJ, Buchko GW, Shaw WJ.  Biophys J. 2018 Nov 6;115(9):1666-1672. doi: 10.1016/j.bpj.2018.08.027. Epub 2018 Aug 29.

8.       Correction of the Marfan Syndrome Pathogenic FBN1 Mutation by Base Editing in Human Cells and Heterozygous Embryos.

Zeng Y, Li J, Li G, Huang S, Yu W, Zhang Y, Chen D, Chen J, Liu J, Huang XX. Mol Ther. 2018 Nov 7;26(11):2631-2637. doi: 10.1016/j.ymthe.2018.08.007. Epub 2018 Aug 14

9.       Cyclin B2 can compensate for Cyclin B1 in oocyte meiosis I.

Li J, Tang JX, Cheng JM, Hu B, Wang YQ, Aalia B, Li XY, Jin C, Wang XX, Deng SL, Zhang Y, Chen SR, Qian WP, Sun QY, Huang XX, Liu YX.  J Cell Biol. 2018 Nov 5;217(11):3901-3911. doi: 10.1083/jcb.201802077. Epub 2018 Aug 10.

10.   Efficient base editing in methylated regions with a human APOBEC3A-Cas9 fusion.

Wang X, Li J, Wang Y, Yang B, Wei J, Wu J, Wang R, Huang XX, Chen J, Yang L.  Nat Biotechnol. 2018 Nov;36(10):946-949. doi: 10.1038/nbt.4198. Epub 2018 Aug 20

11.   The TEA domain family transcription factor TEAD4 represses murine adipogenesis by recruiting the cofactors VGLL4 and CtBP2 into a transcriptional complex.

Zhang W, Xu J, Li J, Guo T, Jiang D, Feng X, Ma X, He L, Wu W, Yin M, Ge L, Wang Z, Ho MS, Zhao Y, Fei Z, Zhang L. J Biol Chem. 2018 Nov 2;293(44):17119-17134. doi: 10.1074/jbc.RA118.003608. Epub 2018 Sep 12.

12.   Generation of gene-edited sheep with a defined Booroola fecundity gene (FecBB) mutation in bone morphogenetic protein receptor type 1B (BMPR1B) via clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated (Cas) 9.

Zhou S, Yu H, Zhao X, Cai B, Ding Q, Huang Y, Li Y, Li Y, Niu Y, Lei A, Kou Q, Huang XX, Petersen B, Ma B, Chen Y, Wang X. Reprod Fertil Dev. 2018 Nov;30(12):1616-1621. doi: 10.1071/RD18086.

13.   CRISPR-Sirius: RNA scaffolds for signal amplification in genome imaging.

Ma H, Tu LC, Naseri A, Chung YC, Grunwald D, Zhang S, Pederson T. Nat Methods. 2018 Nov;15(11):928-931. doi: 10.1038/s41592-018-0174-0. Epub 2018 Oct 30.

14.   m(6)A facilitates hippocampus-dependent learning and memory through YTHDF1.

Shi H, Zhang X, Weng YL, Lu Z, Liu Y, Lu Z, Li J, Hao P, Zhang Y, Zhang F, Wu Y, Delgado JY, Su Y,Patel MJ, Cao X, Shen B, Huang XX. Ming GL, Zhuang X, Song H, He C, Zhou T.    Nature. 2018 Nov;563(7730):249-253. doi: 10.1038/s41586-018-0666-1. Epub 2018 Oct 31.

15.   Active transport of cytoophidia in Schizosaccharomyces pombe.

Li H, Ye F, Ren JY, Wang PY, Du LL, Liu JL.  FASEB J. 2018 Nov;32(11):5891-5898. doi: 10.1096/fj.201800045RR. Epub 2018 May 21.

10月

16.   Comprehensive evaluation of untargeted metabolomics data processing software in feature detection, quantification and discriminating marker selection.

Li Z, Lu Y, Guo Y, Cao H, Wang Q, Shui W. ANALYTICA CHIMICA ACTA, 2018 Oct 31;1029:50-57. doi: 10.1016/j.aca.2018.05.001. Epub 2018 May 4.

17.   Apj+ Vessels Drive Tumor Growth and Represent a Tractable Therapeutic Target.

Zhao H, Tian X, He L, Li Y, Pu W, Liu Q, Tang J, Wu J, Cheng X, Liu Y, Zhou Q, Tan Z, Bai F, Xu F, Smart N, Zhou B. Cell Rep. 2018 Oct 30;25(5):1241-1254.e5. doi: 10.1016/j.celrep.2018.10.015.

18.   Transcription initiation defines kinetoplast RNA boundaries.

Sement FM, Suematsu T, Zhang LY, Yu T, Huang L, Aphasizheva I, Aphasizhev R.  Proc Natl Acad Sci U S A. 2018 Oct 30;115(44):E10323-E10332. doi: 10.1073/pnas.1808981115. Epub 2018 Oct 17.

19.   Filamentation of asparagine synthetase in Saccharomyces cerevisiae.

Zhang S, Ding K,, Shen QJ, Zhao S, Liu JL.  PLoS Genet. 2018 Oct 26;14(10):e1007737. doi: 10.1371/journal.pgen.1007737. eCollection 2018 Oct.

20.   Indoleacetate decarboxylase is a glycyl radical enzyme catalysing the formation of malodorant skatole.

Liu D, Wei Y, Liu X, Zhou Y, Jiang L, Yin J, Wang F, Hu Y, Nanjaraj Urs AN, Liu Y, Ang EL, Zhao S, Zhao H, Zhang Y. Nat Commun. 2018 Oct 11;9(1):4224. doi: 10.1038/s41467-018-06627-x.

21.   Sarcoglycan Alpha Mitigates Neuromuscular Junction Decline in Aged Mice by Stabilizing LRP4.

Zhao K, Shen C, Li L, Wu H, Xing G, Dong Z, Jing H, Chen W, Zhang H, Tan Z, Pan J, Xiong L, Wang H, Cui W, Sun XD, Li S, Huang X, Xiong WC, Mei L. J Neurosci. 2018 Oct 10;38(41):8860-8873. doi: 10.1523/JNEUROSCI.0860-18.2018. Epub 2018 Aug 31.

22.   Trio-Based Deep Sequencing Reveals a Low Incidence of Off-Target Mutations in the Offspring of Genetically Edited Goats.

Li C, Zhou S, Li Y, Li G, Ding Y, Li L, Liu J, Qu L, Sonstegard T Huang XX, Jiang Y, Chen Y, Petersen B, Wang X.  Front Genet. 2018 Oct 4;9:449. doi: 10.3389/fgene.2018.00449. eCollection 2018.

23.   Spatial regulation of signaling by the coordinated action of the protein tyrosine kinases MET and FER.

Zhang J, Wang Z, Zhang S, Chen Y Xiong X, Li X, Tonks NK, Fan GF.  Cell Signal. 2018 Oct;50:100-110. doi: 10.1016/j.cellsig.2018.06.006. Epub 2018 Jun 18.  

24.   Interfilament interaction between IMPDH and CTPS cytoophidia.

Chang CC, Keppeke GD, Sung LY, Liu JL.  FEBS J. 2018 Oct;285(20):3753-3768. doi: 10.1111/febs.14624. Epub 2018 Aug 31.

25.   A post-ingestive amino acid sensor promotes food consumption in Drosophila.

Yang Z, Huang R, Fu X, Wang G, Qi W, Mao D, Shi Z, Shen WL, Wang L,A.  Cell Res. 2018 Oct; 28(10):1013-1025. doi: 10.1038/s41422-018-0084-9. Epub 2018 Sep 12.

26.   CRISPR-Mediated Recording of Mouse Development.

Sun JL. CRISPR J. 2018 Oct;1:314-316. doi: 10.1089/crispr.2018.29036.jls.

9月

27.   Induction of human somatostatin and parvalbumin neurons by expressing a single transcription factor LIM homeobox 6.

Fang Yuan, Xin Chen, Kai-Heng Fang, Yuanyuan Wang, Mingyan Lin, Shi-Bo Xu, Hai-Qin Huo, Min Xu, Lixiang Ma, Yuejun Chen, He SJ , Yan Liu.    Elife. 2018 Sep 25;7. pii: e37382. doi: 10.7554/eLife.37382.

28.   Generation of isogenic single and multiplex gene knockout mice by base editing-induced STOP.

GuangYang,TianyuZhu,ZongyangLu,GuangleiLi,HaoZhang,SongjieFeng,YajingLiu,JiananLiaYuZhang, Chen J, XuejiangGuo,  Huang XX,  Science Bulletin   2018 Sep 15;63(17):1101-1107. doi: 10.1016/j.scib.2018.07.002.

29.   Mammillary body regulates state-dependent fear by alternating cortical oscillations.

Jiang J, Wang GY, Luo W, Xie H, Guan JS. Sci Rep. 2018 Sep 7;8(1):13471. doi: 10.1038/s41598-018-31622-z.

30.  Histidine-Dependent Protein Methylation Is Required for Compartmentalization of CTP Synthase.

Lin WC, Chakraborty A, Huang SC Wang PY, Hsieh YJ, Chien KY, Lee YH, Chang CC, Tang HY, Lin YT, Tung CS, Luo JD, Chen TW, Lin TY, Cheng ML Chen YT, Yeh CT, Liu JL, Sung LY, Shiao MS, Yu JS, Chang YS, Pai LM.  Cell Rep. 2018 Sep 4;24 (10):2733-2745.e7. doi: 10.1016/j.celrep.2018.08.007.

31.   Crystal Structure of ATP-Bound Human ABCF1 Demonstrates a Unique Conformation of ABC Proteins.

Qu L, Jiang Y, Cheng C, Wu D, Meng B, Chen Z, Zhu Y, Shaw N, Ouyang S, Liu ZJ. Structure. 2018 Sep 4;26(9):1259-1265.e3. doi: 10.1016/j.str.2018.05.019. Epub 2018 Jul 12.

32.   A proximity-tagging system to identify membrane protein-protein interactions.

Liu Q, Zheng J, Sun W, Huo Y, Zhang L,  Wang HP, Zhuang M.  Nat Methods. 2018 Sep;15(9):715-722. doi: 10.1038/s41592-018-0100-5. Epub 2018 Aug 13.

8月

33.   Discrimination and quantification of homologous keratins from goat and sheep with dual protease digestion and PRM assays.

Miao C, Yang Y, Li S, Guo Y, Shui W, Cao Q. J Proteomics. 2018 Aug 30;186:38-46. doi: 10.1016/j.jprot.2018.07.010. Epub 2018 Jul 17.

34.   Molecular Basis for the Final Oxidative Rearrangement Steps in Chartreusin Biosynthesis.

Wang YS, Zhang B, Zhu J, Yang CL, Guo Y, Liu CL, Liu F, Huang H, Zhao S, Liang Y, Jiao RH, Tan RX, Ge HM. J Am Chem Soc. 2018 Aug 29;140(34):10909-10914. doi: 10.1021/jacs.8b06623. Epub 2018 Aug 15.

35.   Extracellular matrix protein 1 promotes follicular helper T cell differentiation and antibody production.

He L, Gu W, Wang M, Chang X, Sun X, Zhang Y, Lin X,Yan C, Fan W, Su P, Wang Y, Yi C, Lin G, Li L, Jiang Y, Lu JX, Dong C, Wang H,Sun B.  Proc Natl Acad Sci U S A. 2018 Aug 21;115 (34):8621-8626. doi: 10.1073/pnas.1801196115. Epub 2018 Aug 7.

36.   Crystal structure of the Frizzled 4 receptor in a ligand-free state.

Yang S, Wu Y, Xu TH, de Waal PW, He Y, Pu M, Chen Y, DeBruine ZJ, Zhang B, Zaidi SA, Popov P, Guo Y, Han GW, Lu Y, Suino-Powell K, Dong S, Harikumar KG, Miller LJ, Katritch V, Xu HE, Shui W, Stevens RC,, Melcher K, Zhao S, Xu F.  Nature. 2018 Aug;560(7720):666-670. doi: 10.1038/s41586-018-0447-x. Epub 2018 Aug 22.

37.   Intrinsically Disordered Proteins Link Alternative Splicing and Post-translational Modifications to Complex Cell Signaling and Regulation.

Zhou J, Zhao S, Dunker AK. J Mol Biol. 2018 Aug 3;430(16):2342-2359. doi: 10.1016/j.jmb.2018.03.028. Epub 2018 Apr 4.

38.   miR-221/222 activate the Wnt/beta-catenin signaling to promote triple-negative breast cancer.

Liu S, Wang Z, Liu Z, Shi S, Zhang Z, Zhang J, Lin H. J Mol Cell Biol. 2018 Aug 1;10(4):302-315. doi: 10.1093/jmcb/mjy041.

39.   Real-time observation of nucleoplasmin-mediated DNA decondensation and condensation reveals its specific functions as a chaperone.

Huo XM, Meng LF, Jiang T, Li M Sun FZ, Sun B, Li JK.  Biochim Biophys Acta Gene Regul Mech. 2018 Aug;1861(8):743-751. doi: 10.1016/j.bbagrm.2018.07.002. Epub 2018 Jul 21.

40.   BE-PLUS: a new base editing tool with broadened editing window and enhanced fidelity.

Jiang W, Feng S, Huang S, Yu W, Li G, Yang G, Liu Y, Zhang Y, Zhang L, Hou Y, Chen J, Chen J, Huang XX.  Cell Res. 2018 Aug;28(8):855-861. doi: 10.1038/s41422-018-0052-4. Epub 2018 Jun 6.

7月

41.   Highly efficient and precise base editing by engineered dCas9-guide tRNA adenosine deaminase in rats.

Ma Y, Yu L, Zhang X, Xin C Huang S, Bai L, Chen W, Gao R, Li J, Pan S, Qi X, Huang XX, Zhang L.  Cell Discov. 2018 Jul 17;4:39. doi: 10.1038/s41421-018-0047-9. eCollection 2018.

42.   Exploring a new ligand binding site of G protein-coupled receptors.

Chan HCS, Wang J, Palczewski K, Filipek S, Vogel H, Liu ZJ, Yuan S. Chem Sci. 2018 Jul 13;9(31):6480-6489. doi: 10.1039/c8sc01680a. eCollection 2018 Aug 21.

43.   3D Culture Method for Alzheimer's Disease Modeling Reveals Interleukin-4 Rescues A beta 42-Induced Loss of Human Neural Stem Cell Plasticity.

Papadimitriou C, Celikkaya H, Cosacak MI, Mashkaryan V, Bray L, Bhattarai P, Brandt K, Hollak H, Chen X, He SJ, Antos CL, Lin W, Thomas AK, Dahl A, Kurth T, Friedrichs J, Zhang Y, Freudenberg U, Werner C, Kizil C.  Dev Cell. 2018 Jul 2;46(1):85-101.e8. doi: 10.1016/j.devcel.2018.06.005.

44.   2-Thiophene ethylamine modified hyaluronic acid with its application on hepatocytes culture.

Wang L, Zhou Y, Dai J, Jiang S Lu Y, Sun M, Gong J, Huang PY, Yao Y.  Mater Sci Eng C Mater Biol Appl.2018 Jul 1;88:157-165. doi: 10.1016/j.msec.2018.03.009. Epub 2018 Mar 20.

45.   APOBEC3B and APOBEC mutational signature as potential predictive markers for immunotherapy response in non-small cell lung cancer.

Wang S, Jia M, He Z, Liu XS.   Oncogene. 2018 Jul;37 (29):3924-3936. doi: 10.1038/s41388-018-0245-9. Epub 2018 Apr 26.

46.   Protein crystal quality oriented disulfide bond engineering.

Pu M, Xu Z, Peng Y, Hou Y, Liu D, Wang Y, Liu H, Song G, Liu ZJ. Protein Cell. 2018 Jul;9(7):659-663. doi: 10.1007/s13238-017-0482-7.

6月

47.   Biallelic Mutations in MYORG Cause Autosomal Recessive Primary Familial Brain Calcification.

Yao XP, Cheng X, Wang C, Zhao M, Guo XX, Su HZ, Lai LL, Zou XH, Chen X,J Zhao Y, Dong EL, Lu YQ, Wu S, Li X, Fan GF, Yu H, Xu J, Wang N, Xiong ZQ, Chen WJ.  Neuron. 2018 Jun 27;98(6):1116-1123.e5. doi: 10.1016/j.neuron.2018.05.037. Epub 2018 Jun 14.

48.   DeepCRISPR: optimized CRISPR guide RNA design by deep learning.

Chuai G, Ma H, Yan J, Chen M, Hong N, Xue D, Zhou C, Zhu C, Chen K, Duan B, Gu F, Qu S, Huang D, Wei J, Liu Q. Genome Biol. 2018 Jun 26;19(1):80. doi: 10.1186/s13059-018-1459-4.

49.   Computational design of thermostabilizing point mutations for G protein-coupled receptors.

Popov P, Peng Y, Shen L, Stevens RC, Cherezov V, Liu ZJ, Katritch V. Elife. 2018 Jun 21;7. pii: e34729. doi: 10.7554/eLife.34729.

50.   Glutamine-utilizing transaminases are a metabolic vulnerability of TAZ/YAP-activated cancer cells.

Yang CS, Stampouloglou E, Kingston NM, Zhang LY, Monti S, Varelas X.  EMBO Rep. 2018 Jun; 19(6):e43577. doi: 10.15252/embr.201643577. Epub 2018 Apr 16

51.   Efficient generation of mouse models of human diseases via ABE- and BE-mediated base editing.

Liu Z, Lu Z, Yang G, Huang S, Li G, Feng S, Liu Y, Li J, Yu W, Zhang Y, Chen J, Sun Q ,Huang XX.  Nat Commun. 2018 Jun 14; 9(1):2338. doi: 10.1038/s41467-018-04768-7.

52.   IMP/GTP balance modulates cytoophidium assembly and IMPDH activity.

Keppeke GD, Chang CC, Peng M, Chen LY, Lin WC, Pai LM, Andrade LEC, Sung LY, Liu JL.  Cell Div. 2018 Jun 15;13:5. doi: 10.1186/s13008-018-0038-0. eCollection 2018.

53.   Helicase promotes replication re-initiation from an RNA transcript.

Sun B, Singh A, Sultana S, Inman JT, Patel SS, Wang MD.  Nat Commun. 2018 Jun 13; 9(1):2306. doi: 10.1038/s41467-018-04702-x.

54.   TGFβ signaling hyperactivation-induced tumorigenicity during the derivation of neural progenitors from mouse ESCs.

Yang X, Wang R, Wang X, Cai G, Qian Y, Feng S, Tan F, Chen K, Tang K, Huang XX, Jing N, Qiao Y.  J Mol Cell Biol. 2018 Jun 1;10(3):216-228. doi: 10.1093/jmcb/mjy013.

55.   A LIMA1 variant promotes low plasma LDL cholesterol and decreases intestinal cholesterol absorption.

Zhang YY, Fu ZY, Wei J, Qi W, Baituola G, Luo J, Meng YJ, Guo SY, Yin H, Jiang SY, Li YF, Miao HH, Liu Y, Wang Y, Li BL, Ma YT, Song BL.  Science. 2018 Jun 8;360(6393):1087-1092. doi: 10.1126/science.aao6575.

56.   Succinate-acetate permease from Citrobacter koseri is an anion channel that unidirectionally translocates acetate.

Qiu B, Xia B, Zhou Q, Lu Y,  He M,  Hasegawa K, Ma Z, Zhang F, Gu L, Mao Q, Wang F, Zhao S, Gao Z, Liao J.     Cell Res. 2018 Jun;28(6):644-654. doi: 10.1038/s41422-018-0032-8. Epub 2018 Mar 27.

5月

57.   The Future of Genome Editing.

April Pawluk, Chen J, Prashant Mali, and Weizhi Ji.   Cell Volume.2018 May31;173(6): 1311-1313.

58.   Low incidence of SNVs and indels in trio genomes of Cas9-mediated multiplex edited sheep.

Wang X, Liu J, Niu Y, Li Y, Zhou S, Li C, Ma B, Kou Q, Petersen B, Sonstegard T, Huang XX, Jiang Y, Chen Y.  BMC Genomics. 2018 May 25;19(1):397. doi: 10.1186/s12864-018-4712-z.

59.   Salvianolic acids from antithrombotic Traditional Chinese Medicine Danshen are antagonists of human P2Y(1) and P2Y(12) receptors.

Liu X, Gao Z, Wu Y, Stevens RC, Kenneth A. J, Zhao S.  Sci Rep. 2018 May 24;8(1):8084. doi: 10.1038/s41598-018-26577-0.

60.   Stretchable Transparent Electrode Arrays for Simultaneous Electrical and Optical Interrogation of Neural Circuits in Vivo.

Zhang J, Liu X, Xu W, Luo W, Li M, Chu F, Xu L, Cao A, Guan J, Tang S, Duan X. Nano Lett. 2018 May 9;18(5):2903-2911. doi: 10.1021/acs.nanolett.8b00087. Epub 2018 Apr 9.

61.   Distinct Proteome Remodeling of Industrial Saccharomyces cerevisiae in Response to Prolonged Thermal Stress or Transient Heat Shock.

Xiao W, Duan X, Lin Y, Cao Q, Li S, Guo Y, Gan Y, Qi X, Zhou Y, Guo L, Qin P, Wang Q, Shui W. J Proteome Res. 2018 May 4;17(5):1812-1825. doi: 10.1021/acs.jproteome.7b00842. Epub 2018 Apr 9.

4月

62.   Genome-wide CRISPR screen identifies FAM49B as a key regulator of actin dynamics and T cell activation.

Shang W, Jiang Y, Boettcher M, Ding K, Mollenauer M, Liu Z, Wen X, Liu C, Hao P, Zhao S, McManus MT, Wei L, Weiss A, Wang HP.  Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):E4051-E4060. doi: 10.1073/pnas.1801340115. Epub 2018 Apr 9.

63.   Base editing with a Cpf1-cytidine deaminase fusion.

Li X, Wang Y, Liu Y, Yang B, Wang X, Wei J, Lu Z, Zhang Y, Wu J, Huang X, Yang L, Chen J.  Nat Biotechnol. 2018 Apr;36(4):324-327. doi: 10.1038/nbt.4102. Epub 2018 Mar 19.

3月

64.   Genetic Fate Mapping Defines the Vascular Potential of Endocardial Cells in the Adult Heart.

Tang J, Zhang H, He L, Huang X, Li Y, Pu W, Yu W, Zhang L, Cai D, Lui KO, Zhou B.  Circ Res. 2018 Mar 30;122(7):984-993. doi: 10.1161/CIRCRESAHA.117.312354. Epub 2018 Jan 26.

65.   CRISPR/Cas9-mediated Targeted Integration In Vivo Using a Homology-mediated End Joining-based Strategy.

Yao X, Wang X, Liu J, Shi L, Huang PY, Yang H. J Vis Exp. 2018 Mar 12;(133). doi: 10.3791/56844.

66.   Ubiquitin C-Terminal Hydrolase L1 regulates autophagy by inhibiting autophagosome formation through its deubiquitinating enzyme activity.

Yan C, Huo H, Yang C, Zhang T, Chu Y, Liu YF.  Biochem Biophys Res Commun. 2018 Mar 4;497(2):726-733. doi: 10.1016/j.bbrc.2018.02.140. Epub 2018 Feb 17.

67.   Endocardial Cell Plasticity in Cardiac Development, Diseases and Regeneration.

Zhang H, Lui KO, Zhou B.  Circ Res. 2018 Mar 2;122(5):774-789. doi: 10.1161/CIRCRESAHA.117.312136.

68.   In vivo simultaneous transcriptional activation of multiple genes in the brain using CRISPR-dCas9-activator transgenic mice.

Zhou H, Liu J, Zhou C, Gao N, Rao Z, Li H, Hu X, Li C, Yao X, Shen X, Sun Y, Wei Y, Liu F, Ying W, Zhang J, Tang C, Zhang X, Xu H, Shi L, Cheng L, Huang PY, Yang H.  Nat Neurosci. 2018 Mar;21(3):440-446. doi: 10.1038/s41593-017-0060-6. Epub 2018 Jan 15.

69.   Generation of a precise Oct4-hrGFP knockin cynomolgus monkey model via CRISPR/Cas9-assisted homologous recombination.

Cui Y, Niu Y, Zhou J, Chen Y, Cheng Y, Li S, Ai Z, Chu C, Wang H, Zheng B, Chen X, Sha J, Guo X, Huang XX, Ji W.  Cell Res. 2018 Mar;28(3):383-386. doi: 10.1038/cr.2018.10. Epub 2018 Jan 12.

2月

70.   Generation of GHR-modified pigs as Laron syndrome models via a dual-sgRNAs/Cas9 system and somatic cell nuclear transfer.

Yu H, Long W, Zhang X, Xu K, Guo J, Zhao H, Li H, Qing Y, Pan W, Jia B, Zhao HY, Huang XX, Wei HJ.  J Transl Med. 2018 Feb 27;16(1):41. doi: 10.1186/s12967-018-1409-7.

71.   High-throughput identification of G protein-coupled receptor modulators through affinity mass spectrometry screening.

Qin S, Meng M, Yang D, Bai W, Lu Y, Peng Y, Song G, Wu Y, Zhou Q, Zhao S, Huang X, McCorvy JD, Cai X, Dai A, Roth BL, Hanson MA, Liu ZJ, Wang MW,Stevens RC, Shui W.  Chem Sci. 2018 Feb 20;9(12):3192-3199. doi: 10.1039/c7sc04698g. eCollection 2018 Mar 28.

72.   Implantable and Biodegradable Poly(l‐lactic acid) Fibers for Optical Neural Interfaces.

Ruxing Fu, Wenhan Luo, Roya Nazempour, Daxin Tan, He Ding, Kaiyuan Zhang, Lan Yin, Guan JS, Xing Sheng.  Advanced Optical Materials . 2018 Feb 5;6(3). 1700941 doi: 10.1002/adom.201700941

73.   Lateral habenula in the pathophysiology of depression.

Yang Y, Wang H, Hu J, Hu H.  Curr Opin Neurobiol. 2018 Feb;48:90-96. doi: 10.1016/j.conb.2017.10.024. Epub 2017 Nov 23.

74.   5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology.

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75.   Production of Wilson Disease Model Rabbits with Homology-Directed Precision Point Mutations in the ATP7B Gene Using the CRISPR/Cas9 System.

Jiang W, Liu L, Chang Q, Xing F, Ma Z, Fang Z, Zhou J, Fu L, Wang H, Huang XX, Chen X, Li Y, Li S. Sci Rep. 2018 Jan 22;8(1):1332. doi: 10.1038/s41598-018-19774-4

76.   Clonal analysis of lineage fate in native haematopoiesis.

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77.   Genomic Tagging of AGO1 Using CRISPR/Cas9-Mediated Homologous Recombination.

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78.   APOBEC3 induces mutations during repair of CRISPR-Cas9-generated DNA breaks.

Lei L, Chen H, Xue W, Yang B, Hu B, Wei J, Wang L, Cui Y, Li W, Wang J, Yan L, Shang W, Gao J, Sha J, Zhuang M, Huang XX, Shen B, Yang L, Chen J.  Nat Struct Mol Biol. 2018 Jan;25(1):45-52. doi: 10.1038/s41594-017-0004-6. Epub 2017 Dec 11.

79.   Efficient generation of goats with defined point mutation (I397V) in GDF9 through CRISPR/Cas9.

Niu Y, Zhao X, Zhou J, Li Y, Huang Y, Cai B, Liu Y, Ding Q, Zhou S, Zhao J, Zhou G, Ma B, Huang XX, Wang X, Chen Y.  Reprod Fertil Dev. 2018 Jan;30(2):307-312. doi: 10.1071/RD17068.

80.   CRL4 antagonizes SCFFbxo7-mediated turnover of cereblon and BK channel to regulate learning and memory.

Song T, Liang S, Liu J, Zhang T, Yin Y, Geng C, Gao S, Feng Y, Xu H, Guo D, Roberts A, Gu Y, Cang Y.  PLoS Genet. 2018 Jan 25;14(1):e1007165. doi: 10.1371/journal.pgen.1007165. eCollection 2018 Jan.

81.   Identification of natural products as novel ligands for the human 5-HT2C receptor.

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